This paper discusses the Space Shuttle Lift-off CFD model developed for potential Lift-off Debris transport for return-to-flight. The Lift-off portion of the flight is defined as the time starting with tanking of propellants until tower clear, approximately T0+6 seconds, where interactions with the launch pad cease. A CFD model containing the Space Shuttle and launch Pad geometry has been constructed and executed. Simplifications required in the construction of the model are presented and discussed. A body-fitted overset grid of up to 170 million grid points was developed which allowed positioning of the Vehicle relative to the Launch Pad over the first six seconds of Climb-Out. The CFD model works in conjunction with a debris particle transport model and a debris particle impact damage tolerance model. These models have been used to assess the interactions of the Space Shuttle plumes, the wind environment, and their interactions with each other and the Launch Pad and their ultimate effect on potential debris during Lift-off.